Medical & Research Advisors
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Our advisers role is primarily to contribute expertise to LLF regarding the research of HLH, LCH and other histiocytic disorders, current literature and publications, and any information that is needed by LLF regarding HLH and other histiocytic disorders. This group of physicians is not a governing board. It provides guidance and insight directly to LLF to ensure that the research of HLH, LCH, and other histiocytic disorders is part of LLF's scientific framework.
The list of physicians below is made up of expert researchers in the area of Histiocytosis. The primary function is to consult with LLF in order to provide the correct and most up-to-date information regarding the hlh, lch and it's treatments. *Note these physicians and their respective employers do not QC and approve daily medical content on the site* |
Alexandra (Lisa) H. Filipovich, MD (Retired)
Director,Immune Deficiency and Histiocytosis Program
Cincinnati Children's Hospital Medical Center, Ralph J. Stolle Chair, Clinical Immunology, Medical Director Diagnostic Immunology Laboratory, Professor, UC Department of Pediatrics
Lisa Filipovich, MD, began her career at the University of Minnesota where she received her medical degree in 1974 and completed fellowships in both immunopathology and pediatric immunology. She became a professor of pediatrics and served for ten years as the head of the Division of Immunology at the University of Minnesota Medical School. Dr. Filipovich came to Cincinnati Children’s Hospital Medical Center in 1996. She is currently the Ralph J. Stolle Chair in Clinical Immunology and the director of the Immune Deficiency and Histiocytosis program. She also serves as the medical director of the Diagnostic Immunology Laboratory at Cincinnati Children’s.
Dr. Filipovich has a special interest in histiocytic disorders, especially Hemophagocytic Lymphohistiocytosis (HLH). Other interests include bone marrow transplant for primary immune deficiencies and post-BMT immune reconstitution. She serves as president of the Histiocyte Society, an international group of more than 200 physicians and scientists who are committed to improving the lives of patients with histiocytosis through research.
Cincinnati Children's Hospital Medical Center, Ralph J. Stolle Chair, Clinical Immunology, Medical Director Diagnostic Immunology Laboratory, Professor, UC Department of Pediatrics
Lisa Filipovich, MD, began her career at the University of Minnesota where she received her medical degree in 1974 and completed fellowships in both immunopathology and pediatric immunology. She became a professor of pediatrics and served for ten years as the head of the Division of Immunology at the University of Minnesota Medical School. Dr. Filipovich came to Cincinnati Children’s Hospital Medical Center in 1996. She is currently the Ralph J. Stolle Chair in Clinical Immunology and the director of the Immune Deficiency and Histiocytosis program. She also serves as the medical director of the Diagnostic Immunology Laboratory at Cincinnati Children’s.
Dr. Filipovich has a special interest in histiocytic disorders, especially Hemophagocytic Lymphohistiocytosis (HLH). Other interests include bone marrow transplant for primary immune deficiencies and post-BMT immune reconstitution. She serves as president of the Histiocyte Society, an international group of more than 200 physicians and scientists who are committed to improving the lives of patients with histiocytosis through research.
Michael B. Jordan, MD
Associate Professor, UC Department of Pediatrics
Clinical Interests include Histiocytic disorders: HLH and LCH
Research Interests: Better understanding histiocytic disorders and developing novel therapies for them; regulation of the immune response; immunotherapy of cancer
Education and Training:
MD: UT Southwestern, Dallas, TX 1993.
Residency: Children's Hospital of Dallas, 1996.
Fellowship: The Children's Hospital (Denver) 2002.
Certification: American Board of Pediatrics, 1996; Sub-board of Pediatric Heme/Onc 2002.
Clinical Interests include Histiocytic disorders: HLH and LCH
Research Interests: Better understanding histiocytic disorders and developing novel therapies for them; regulation of the immune response; immunotherapy of cancer
Education and Training:
MD: UT Southwestern, Dallas, TX 1993.
Residency: Children's Hospital of Dallas, 1996.
Fellowship: The Children's Hospital (Denver) 2002.
Certification: American Board of Pediatrics, 1996; Sub-board of Pediatric Heme/Onc 2002.
Kimberly A. Risma, MD, PhD
Director, Allergy and Immunology Fellowship Program
Assistant Professor, UC Department of Pediatrics
Clinical Interests: Immune deficiency; immune dysregulation
Research InterestsPathophysiology of perforin missense mutations identified in individuals with hemophagocytic lymphohistiocytosis; molecular mechanisms of primary immune deficiency and dysregulation; natural killer cell and cytotoxic T lymphocyte cytotoxicity
Biography
Kimberly Risma, MD, PhD, is an assistant professor in the Division of Allergy and Immunology at Cincinnati Children’s and the University of Cincinnati College of Medicine.
Dr. Risma graduated magna cum laude with a Bachelor of Arts in Chemistry from Duke University in 1990 and was elected into The Phi Beta Kappa Society. She then matriculated at Case Western Reserve University (CWRU) School of Medicine in the Medical Scientist Training Program (MSTP). In 1996, she completed a PhD in pharmacology. She was selected by the leadership of the CWRU MSTP as the recipient of the 1997 Martin Wahl Memorial Fund Award, given annually to recognize the graduating MD, PhD student who has demonstrated the highest level of independence in research and excellence in research and clinical skills. She was also elected to Alpha Omega Alpha Society in 1997.
In 1997, she enrolled in a Pediatrics residency at Cincinnati Children’s Hospital Medical Center/University of Cincinnati. During the residency program, Dr. Risma was awarded the pediatric resident teaching award by the medical students. She also engaged in translational research studies related to the genetics of asthma under the mentorship of Dr. Gurjit Hershey, resulting in a first author publication as a pediatric resident.
In 2000, Dr. Risma was accepted to the Allergy and Immunology Fellowship Program at Cincinnati Children’s. In addition to her clinical training, she pursued an innovative research project under the mentorship of Dr. Janos Sumegi and Dr. Alexandra Filipovich. She proposed a mechanism to study the structural and functional impact of perforin missense mutations identified in patients with hemophagocytic lymphohistiocytosis. In 2004 she was awarded the Nezelof Prize for best scientific presentation at the international meeting of the Histiocyte Society. The culmination of her fellowship research project was published in the Journal of Clinical Investigation, 2006.
Upon completion of her fellowship in 2005, Dr. Risma was appointed as an Assistant Professor in the Division of Allergy and Immunology at Cincinnati Children’s Hospital Medical Center. In 2006 Dr. Risma received a Clinical Scientist Development Award from the Doris Duke Charitable Foundation. Dr. Risma is the director of the Allergy and Immunology Fellowship Program at Cincinnati Children's, having served in this leadership position since August of 2012.
Dr. Risma's research program focuses on understanding the molecular mechanisms of immunodeficiency and immune dysregulation in children, especially as it relates to disorders of lymphocyte cytotoxicity. In addition to her research, she sees patients from all around the country in consultation for primary immune deficiency, immune dysregulation, and allergic disorders.
Education and Training
MD: Case Western Reserve University School of Medicine, Cleveland, OH, 1997.
PhD: Case Western Reserve University School of Medicine, Cleveland, OH, 1996.
Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, 1997-2000.
Fellowship: Allergy / Immunology, Cincinnati Children's Hospital Medical Center.
Certification: Pediatrics, 2007; Allergy and Immunology, 2005.
Assistant Professor, UC Department of Pediatrics
Clinical Interests: Immune deficiency; immune dysregulation
Research InterestsPathophysiology of perforin missense mutations identified in individuals with hemophagocytic lymphohistiocytosis; molecular mechanisms of primary immune deficiency and dysregulation; natural killer cell and cytotoxic T lymphocyte cytotoxicity
Biography
Kimberly Risma, MD, PhD, is an assistant professor in the Division of Allergy and Immunology at Cincinnati Children’s and the University of Cincinnati College of Medicine.
Dr. Risma graduated magna cum laude with a Bachelor of Arts in Chemistry from Duke University in 1990 and was elected into The Phi Beta Kappa Society. She then matriculated at Case Western Reserve University (CWRU) School of Medicine in the Medical Scientist Training Program (MSTP). In 1996, she completed a PhD in pharmacology. She was selected by the leadership of the CWRU MSTP as the recipient of the 1997 Martin Wahl Memorial Fund Award, given annually to recognize the graduating MD, PhD student who has demonstrated the highest level of independence in research and excellence in research and clinical skills. She was also elected to Alpha Omega Alpha Society in 1997.
In 1997, she enrolled in a Pediatrics residency at Cincinnati Children’s Hospital Medical Center/University of Cincinnati. During the residency program, Dr. Risma was awarded the pediatric resident teaching award by the medical students. She also engaged in translational research studies related to the genetics of asthma under the mentorship of Dr. Gurjit Hershey, resulting in a first author publication as a pediatric resident.
In 2000, Dr. Risma was accepted to the Allergy and Immunology Fellowship Program at Cincinnati Children’s. In addition to her clinical training, she pursued an innovative research project under the mentorship of Dr. Janos Sumegi and Dr. Alexandra Filipovich. She proposed a mechanism to study the structural and functional impact of perforin missense mutations identified in patients with hemophagocytic lymphohistiocytosis. In 2004 she was awarded the Nezelof Prize for best scientific presentation at the international meeting of the Histiocyte Society. The culmination of her fellowship research project was published in the Journal of Clinical Investigation, 2006.
Upon completion of her fellowship in 2005, Dr. Risma was appointed as an Assistant Professor in the Division of Allergy and Immunology at Cincinnati Children’s Hospital Medical Center. In 2006 Dr. Risma received a Clinical Scientist Development Award from the Doris Duke Charitable Foundation. Dr. Risma is the director of the Allergy and Immunology Fellowship Program at Cincinnati Children's, having served in this leadership position since August of 2012.
Dr. Risma's research program focuses on understanding the molecular mechanisms of immunodeficiency and immune dysregulation in children, especially as it relates to disorders of lymphocyte cytotoxicity. In addition to her research, she sees patients from all around the country in consultation for primary immune deficiency, immune dysregulation, and allergic disorders.
Education and Training
MD: Case Western Reserve University School of Medicine, Cleveland, OH, 1997.
PhD: Case Western Reserve University School of Medicine, Cleveland, OH, 1996.
Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, 1997-2000.
Fellowship: Allergy / Immunology, Cincinnati Children's Hospital Medical Center.
Certification: Pediatrics, 2007; Allergy and Immunology, 2005.
Kenneth McClain, M.D., Ph.D.
Department of Pediatrics
Section of Hematology-Oncology
Baylor College of Medicine
Director, Histiocytosis Program
Texas Children's Cancer & Hematology Centers
Dr. Ken McClain is a member of the leukemia and lymphoma teams of the Texas Children’s Cancer Center. His research is focused on the clinical and biologic aspects of Langerhans cell histiocytosis (LCH). He is a key member of the clinical trials group of the Histiocyte Society.
Dr. McClain and Dr. Carl Allen see 100 new patients with a variety of histiocytic diseases each year. A number of clinical studies are in progress or development including new therapeutic interventions for CNS LCH. Current biologic studies in his lab are focused on determining the gene expression profiles Langerhans cells and lymphocytes from control and patient tissues and making clinical correlations. Learn about Dr. McClain's Histiocytosis Research
Education
M.D. and Ph.D., University of Chicago School of Medicine
Residency, The Johns Hopkins Hospital
Postdoctoral Research, National Institute of Child Health, Laboratory of Molecular Genetics
Fellowship, University of Minnesota School of Medicine
Board Certifications
American Board of Pediatrics: Pediatrics and Pediatric Hematology/Oncology
Selected Memberships
Past-President, Histiocyte Society
Member, American Society of Hematology
Member, American Society of Pediatric Hemaotlogy/Oncology
Past-President, Gulf Coast Hematolgy Society
Board Member, Histiocytosis Association of America
Clinical Special Interests
Hematologic Disorders
Leukemia
Lymphoma
Histiocytosis
Sickle Cell Disease
Research Interests
Clinical and biologic aspects of Langerhans cell histiocytosis (LCH)
Gene expression profiles
Section of Hematology-Oncology
Baylor College of Medicine
Director, Histiocytosis Program
Texas Children's Cancer & Hematology Centers
Dr. Ken McClain is a member of the leukemia and lymphoma teams of the Texas Children’s Cancer Center. His research is focused on the clinical and biologic aspects of Langerhans cell histiocytosis (LCH). He is a key member of the clinical trials group of the Histiocyte Society.
Dr. McClain and Dr. Carl Allen see 100 new patients with a variety of histiocytic diseases each year. A number of clinical studies are in progress or development including new therapeutic interventions for CNS LCH. Current biologic studies in his lab are focused on determining the gene expression profiles Langerhans cells and lymphocytes from control and patient tissues and making clinical correlations. Learn about Dr. McClain's Histiocytosis Research
Education
M.D. and Ph.D., University of Chicago School of Medicine
Residency, The Johns Hopkins Hospital
Postdoctoral Research, National Institute of Child Health, Laboratory of Molecular Genetics
Fellowship, University of Minnesota School of Medicine
Board Certifications
American Board of Pediatrics: Pediatrics and Pediatric Hematology/Oncology
Selected Memberships
Past-President, Histiocyte Society
Member, American Society of Hematology
Member, American Society of Pediatric Hemaotlogy/Oncology
Past-President, Gulf Coast Hematolgy Society
Board Member, Histiocytosis Association of America
Clinical Special Interests
Hematologic Disorders
Leukemia
Lymphoma
Histiocytosis
Sickle Cell Disease
Research Interests
Clinical and biologic aspects of Langerhans cell histiocytosis (LCH)
Gene expression profiles
